© 2008
Brychem Business Consulting
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Brychem
has specific experience in the following sectors, technologies and products:
- Regional Sectors
Western and Central Europe (Czech Republic, Hungary, Poland, Romania, Serbia, Slovakia and Slovenia), Asia (Japan, India, Taiwan, China, Korea), South Africa and the USA.
- Fine Chemical Technologies
Chiral chemistry, low temperature reactions, Grignard reactions, peptide synthesis, chiral HPLC, natural product extractions, reductions (hydrogenation, Rosenmund, metal hydride, transfer hydrogenations), Ritter reaction and fluorinations (hydrogen fluoride, halex and Balz-Schiemann).
The application of biotechnology and chiral chemistry in fine chemical manufacture is a speciality.
- Recent studies have been undertaken in the field of biopharmaceuticals, with the emphasis being upon the opportunities in contract manufacturing.
- Technologies for Chemical Intermediates
Aziridine, aromatic nitrations, fluorinations, phosgenation, chlorophenols, high-pressure hydrogenations, dimethyl sulphate, hydrogen cyanide, aromatic methoxylations, air-oxidations, brominations, gas-phase reactions, thiochemistry, use of protecting groups in peptide and other complex syntheses.
- Basic Chemical Intermediates
Acid chlorides, p-anisaldehyde, aniline, anthranilic acid, pentafluorobromobenzene, chloroformates, cyanogen chloride, cyclohexylamine, 2,6-difluorobenzonitrile, perfluorinated aromatics, 2-ethyloxazoline, furfural and its derivatives, glyoxylic acid, p-hydroxybenzaldehyde, p-nitrochlorobenzene, phenylenediamines, pyridines, substituted benzoic acids, xylenols.
- Pharmaceutical Fine Chemicals
Active ingredients: anti-ulcerants (cimetidine, ranitidine, omeprazole), ACE-inhibitors (captopril, enalapril, lisnopril), ß-blockers (metoprolol, atenolol), antibiotics (cephalosporins, chloramphenicol, macrolides, penicillins, quinolones and sulphonamides), NSAID's (nabumetone, naproxen, ibuprofen), prostaglandins (misoprostol, alprostadil, dinoprostone), protease-inhibitors (nelfinavir, saquinavir, amprenavir), melatonin, phentermine, sumatriptan, zolmitriptan, analgesics (aspirin, paracetamol), narcotics (codeine, morphine, buprenorphine), antivirals (acyclovir, abacavir, efavirenz, nevirapine, lamivudine), steroids (hydrocortisone, levonorgestrel, trenbolone acetate, etc) and X-ray contrast media (iohexol, iopamidol).
Intermediates: aromatics (MEP, 3,4,5-TMBA, 1,3,5-TMB, ASC, PNBA, piperonal, p-nitrobenzyl bromide, CFA, isobutylbenzene, sesamol, SMIFA, tryptamine), aliphatics (novaldiamine, oxalyl chloride, fluorene derivatives, chlorosulphonyl isocyanate, butyrolactone, etc), brominated and iodinated intermediates and homochiral intermediates (D-(-)-p-hydroxyphenylglycine, S-AMPA, l-amine, chiral oxiranes, Vince's gamma-lactam).
- Agrochemicals
Active ingredients: atrazine, chlorothalonil, chlorpyrifos, clothianidin, deltamethrin, glyphosate, imidacloprid, lindane, metolachlor, pendimethalin, metamitron, prochloraz, spinosad, terbufos, tefluthrin.
Intermediates: monoisocyanates, chloroformates, diethanolamine, imidazoles, chlorophenols (4-CP, 2,4-DCP, 2,4,6-TCP), cyanuric chloride, cycloproylamine, cyclopropylmethylketone, iminodiacetic acid,m-phenoxybenzaldehyde, cyanogen chloride, organo-fluorine, sulphur and phosphorus intermediates and 2,6-dialkylanilines.
- Other applications
Food additives and ingredients: inulin, lactic acid, artificial sweeteners (aspartame, cyclamate, saccharin, sucralose, acesulfame-K, NHDC), natural colorants (carotenoids) and flavours (maltol, nootkatone, corylone) and natural amino acids (especially l-phenylalanine, l-arginine, l-glutamine, d,l-methionine, l-aspartic acid and l-lysine).
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